Generic Name: Montelukast 5mg
Manufacturer/Distributor: Delta Pharma Limited
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Indications
Montelukast Sodium is indicated for:
Pharmacology
Montelukast inhibits the cysteinyl leukotriene receptor and is a selective and orally active leukotriene receptor antagonist (CysLT1). Arachidonic acid metabolism produces cysteinyl leukotrienes (LTC4, LTD4, LTE4), which are produced by a variety of cells, including mast cells and eosinophils. The pathophysiology of asthma and allergic rhinitis, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, have been linked to cysteinyl leukotrienes and leukotriene receptor occupation, all of which contribute to the signs and symptoms of asthma.
Dosage
Adults & adolescents (15 years & older)-
Asthma & Allergic Rhinitis: 10 mg/day
Exercise-Induced Bronchoconstriction: 10 mg/day
Pediatric patients (6 to 14 years)-
Asthma & Allergic Rhinitis: 5 mg/day
Exercise-Induced Bronchoconstriction: 5 mg/day
Pediatric patients (6 months to 5 years)-
Asthma & Allergic Rhinitis: 4 mg/day
Exercise-Induced Bronchoconstriction: Not recommended
Patients with both asthma and allergic rhinitis should take only one dose daily in the evening. For prevention of Acute prevention of Exercise-Induced Bronchoconstriction, a single dose should be taken at least 2 hours before exercise.
Administration
Route of administration: Oral. Montelukast may be taken with or without food or as directed by the physician.
Interaction
With medicine: No dose adjustment is needed when montelukast is co-administered with theophylline, prednisone, prednisolone, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative-hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, decongestants, oral contraceptives, and Cytochrome P450 (CYP) enzyme inducers.
With food and others: Bioavailability and other conditions were not significantly observed with food & other conditions.
Contraindications
Patients who are hypersensitive to any component of Montelukast should avoid using it.
Side Effect
Diarrhea, fever, gastrointestinal distress, headache, nausea, vomiting, skin responses, and upper respiratory tract infection are all common symptoms.
Akathisia, anxiety, arthralgia, asthenia, aberrant behavior, depression, dizziness, drowsiness, dry mouth, hemorrhage, irritability, malaise, muscular complaints, edema, seizure, odd feeling, and sleep problems are all uncommon symptoms.
Angioedema, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic problems, memory loss, palpitations, pulmonary eosinophilia, suicidal inclinations, tremors are all uncommon symptoms.
Pregnancy & Lactation
In pregnant women, there are no appropriate and well-controlled trials. Montelukast should only be taken during pregnancy if it is absolutely necessary. Montelukast is a medication that is secreted in breast milk. When Montelukast is administered to a nursing woman, vigilance should be used.
Precautions & Warnings
Montelukast is not suitable for reversing the bronchospasm of an acute asthma attack (including the state of asthma). Neuropsychiatric events include agitation, hostility, anxiety, depression, disorientation, attention disorders, abnormal dreams, hallucinations, insomnia, irritability, memory disorders, irritability, sleepwalking, suicidal thoughts and behaviors (including suicide), and tremors.
Storage Conditions
Keep away from light and heat in a dry area. Keep out of children's reach.
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